Seasonal Pasture Myopathy, a highly fatal muscle disease has long been recognised in the US. It is very similar to the atypical myopathy recognised in Northern Europe.

For the first time, SPM has been linked to a toxin in box elder seeds abundant on autumn pastures whose metabolyte hypoglycin can create the pathology recognised in both SPM and AM. Further research is required to determine factors that affect annual seed burden and hypoglycin A content in tree species prevalent in the US and Europe but this study represents an important step towards understanding this devastating condition.

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